NGS Panel Myeloide
Recherche de mutations impliquées dans les héomathies myéloïdes (92 gènes) :
ABL2, ANKRD26, ASXL1, ATRX, BCOR, BCORL1, BRAF, BRCC3, BTK, CALR, CBL, CBLB, CBLC, CCND2, CDC25C, CDKN2A, CEBPA, CREBBP, CSF3R, CTCF, CUX1, CXCR4, DCK, DDX41, DHX15, DNMT3A, EED, ETNK1, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GNAS, GNB1, HRAS, IDH1, IDH2, IKZF1, IL7R, JAK2, JAK3, KDM6A, KIT, KMT2A, KMT2D, KRAS, LUC7L2, MAP2K1, MPL, MYC, MYD88, NF1, NOTCH1, NPM1, NRAS, NUDT15, PAX5, PDGFRA, PHF6, PPM1D, PRPF8, PTEN, PTPN11, RAD21, RBBP6, RPS14, RUNX1, SAMD9, SAMD9L, SETBP1, SF3B1, SH2B3, SLC29A1, SMC1A, SMC3, SRSF2, STAG2, STAT3, STAT5B, TET2, TP53, TPMT, U2AF, U2AF2, UBA1, UBTF, WT1, XPO1, ZRSR2
NGS Panel Lymphoîde
Recherche de mutations géniques impliquées dans les hémpathies lymphoîdes (51 gènes) :
ARID1A, ATM, B2M, BCL2, BIRC3, BRAF, BTK, CARD11, CCND1, CD28, CD79B, CDKN2A, CDKN2B, CREBBP, CXCR4, DNMT3A, EP300, EZH2, FOXO1, ID3, IDH2, JAK1, JAK3, KLF2, KMT2D, MEF2B, MYC, MYD88, NFKBIE, NOTCH1, NOTCH2, PIM1, PLCG1, PLCG2, PTPRD, RHOA, SF3B1, SOCS1, STAT3, STAT5B, STAT6, TCF3, TET2, TNFAIP3, TNFRSF14, TP53, TRAF2, XPO1, PTEN, NRAS
Panel NGS-SMD (Syndrome Myélodysplasique)
Recherche de mutations sur un panel de gènes ciblés par technique de séquencage haut-débit (42 gènes) :
ASXL1, BCOR, BCORL1, BRAF, CALR, CBL, CEBPA, CSF3R, DNMT3A, ETNK1, ETV6, EZH2, FLT3, GATA2, GNB1, HRAS, IDH1, IDH2, JAK2, KIT, KMT2A-MLL, KRAS, MPL, NF1, NPM1, NRAS, PHF6, PPM1D, PRPF8, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, STAG2, STAT5B, TET2, TP53, UBA1, U2AF1, WT1, ZRSR2